Program

Program

NOVEMBER 6th 2023

13:00 – 14:30 REGISTRATION AND POSTER SET UP

14:30 – 15:00 WELCOME BY PIERA VALENTI, CLAUDIO MARIA MASTRONIANNI AND BO LONNERDAL

PLENARY SECTION
(All the presentations include 5 min of discussion)

CHAIR PERSONS: BO LONNERDAL AND PIERA VALENTI

15:00 LACTOFERRIN AND ITS PEPTIDES: CHARACTERIZATION AND CONTROL QUALITY

15:00 – 15:45 VOGEL Hans J

Department of Biological Sciences, University of Calgary, Canada

Lactoferrin, functional protein-protein interactions and release of bioactive peptides

15:45 – 16:10 JUAREZ PEREZ Victor

Alaxia SAS, Lyon, France

Pharma Grade Lactoferrin. A Regulatory Perspective

16:10 – 16:30 OBERČKAL Jernej

Arhel Ltd, Pod lipami, Komenda, Slovenia

Isolation of lactoferrin from acid whey: increasing the capacity of the cation exchange chromatographic extraction on CIMmultus® SO3 monolithic column

16:30-17:00 COFFEE BREAK

17:00 – 17:30 CASTAGNA Vanessa

TurtleTree Pte. Ltd., 1100 Main Street, Suite 300, Woodland, CA, USA

Fermentation-Derived Bovine Lactoferrin: Expanding Market Opportunities with a Biosimilar Ingredient

17:30 – 17:50 SHARMA Sujata

Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India

C-lobe of Lactoferrin: Understanding the full potential of the half-molecule of a moonlighting protein

17:50 – 18:20 ROSA Luigi

Department of Public Health and Infectious Diseases, University of Rome La Sapienza, Rome, Italy

Influence of sialic acid of lactoferrin in its antibacterial, antiviral and antiinflammatory activities

18:20 – 19:00 POSTER SECTION

19:00 WELCOME PARTY

NOVEMBER 7th 2023

CHAIR PERSONS: ANTHONY B. SCHRYVERS AND LUCA BIANCHI

09:00 LACTOFERRIN AND INFECTIOUS DISEASES
(All the presentations include 5 min of discussion)

09:00 – 09:45 LONNERDAL Bo

Department of Nutrition, University of California, Davis, USA

Antiviral activities of different lactoferrins

09:45 – 10:10 PIACENTINI Roberta (AWARD)

Department of Biochemistry, Sapienza University, Rome, Italy

Lactoferrin inhibition of the complex formation between ACE2 receptor and SARS-CoV-2 recognition binding domain

10:10 – 10:30 CAMPIONE Elena

Unit of Dermatology, Systems Medicine, University of Rome Tor Vergata, Rome, Italy

Lactoferrin assumption in vaccinated subjects infected by SARS-CoV-2 influenced time length of negativization (November 2021-March 2022)

10:30 – 11:00 COFFEE BREAK

CHAIR PERSONS: ANTHONY B. SCHRYVERS AND MARIA PIA CONTE

11:00 – 11:40 LEON-SICAIROS Nidia

Laboratorio de Biologia Celular, Facultad de Medicina, Universidad Autonoma de Sinaloa, Mexico

Lactoferrin and derived peptides avoid glucose assimilation in fungal pathogens

11:40 – 12:00 RUIZ-MAZÓN Lucero

Centro de Investigación y de Estudios Avanzados del IPN, CdMx, Mexico

Effect of bovine lactoferrin on biofilm formation of Mannheimia haemolytica A2

12:00 – 12:40 WANG Jianhua

Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijng, China

Branched chimeric lactoferricin and its antimicrobial properties

13:00 – 15:00 LUNCH

 

CHAIR PERSONS : HANS VOGEL AND GIOVANNI MUSCI

15:00 LACTOFERRIN RECEPTORS AND LOCALIZATION
(All the presentations include 5 min of discussion)

15:00 – 15:40 SCHRYVERS Anthony B.

Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, Calgary, Canada

Lactoferrin – bacterial interactions: how prevalent are lactoferrin receptors in Gram-negative bacteria?

15:40 – 16:00 CHAN Clement

Department of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, Calgary, Canada

Evaluating bacterial transferrin/lactoferrin binding proteins-based vaccine antigens using a mutant Neisseria meningitidis strain expressing an exogenous transferrin/lactoferrin receptor

16:00 LACTOFERRIN: IRON AND INFLAMMATORY HOMEOSTASIS
(All the presentations include 5 min of discussion)

16:00 – 16:40 VALENTI Piera

Department of Public Health and Infectious Diseases, University of Rome La Sapienza, Rome, Italy

The efficacy of a novel lactoferrin mixture in restoring iron and inflammatory homeostasis disorders in anemic patients

16:40 – 17:00 COFFEE BREAK

17:00 – 17:30 CUTONE Antimo

Department of Biosciences and Territory, University of Molise, Pesche, Italy

Iron saturation drives lactoferrin effects on HIV Tat-mediated oxidative stress and neurotoxicity

17:30 – 17:50 COSTANZO Anna Maria

Pharmaguida s.r.l., Rome, Italy

Lactoferrin efficacy in treating hyperferritinemia in patients suffering from pathologies unrelated and related to hemochromatosis

17:50 – 18:20 CHRISTOFI Maria-Dolores (AWARD)

Department of Nursing, School of Health Sciences, Cyprus University of Technology, Cyprus

The effectiveness of oral bovine Lactoferrin compared to oral iron supplementation in patients with a low hemoglobin profile: A systematic review and meta-analysis of randomized clinical trials

18:20 – 19:00 POSTER SECTION

NOVEMBER 8th 2023

CHAIR PERSONS: THERESA J. OCHOA AND ANTIMO CUTONE

09:00 BREAST MILK AND INFANT FORMULA
(All the presentations include 5 min of discussion)

09:00 – 09:30 BJÖRMSJÖ Maria

Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden

The LIME study: Clinical effects of reduced iron content and fortification with bovine lactoferrin in infant formula

09:30 – 09:50 NAVARRO Rafaella

Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru

Determinant of lactoferrin concentration in human milk in Peru

09:50 MILK AND COLOSTRUM VERSUS LACTOFERRIN
(All the presentations include 5 min of discussion)

09:50 – 10:10 ROSA Luigi

Department of Public Health and Infectious Diseases, University of Rome La Sapienza, Rome, Italy

Antibacterial, antiinvasive and antiinflammatory activities of bovine lactoferrin extracted from colostrum and milk versus colostrum

10:10 – 10:30 SÁNCHEZ Lourdes

Departamento de Producción Animal y Ciencia de los Alimentos, Facultad de Veterinaria, Universidad de Zaragoza, Zaragoza, Spain

Lactoferrin enriched whey and buttermilk based formulas prevent neuroinflammation and serotonergic alterations in a murine model of DSS-induced ulcerative colitis

10:30 – 11:00 COFFEE BREAK

11:00 – 11:30 ADAM Katharine

Quantec Ltd, Hamilton, New Zealand

In Vivo effects of IDP® on antibody responses to the influenza vaccine

11:30 LACTOFERRIN FUNCTIONS FROM IN VITRO TO IN VIVO STUDIES
– PEDIATRICS
(All the presentations include 5 min of discussion)

11:30 – 12:10 OCHOA Theresa J.

Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru

Role of lactoferrin on pediatric infections

12:10 – 12:50 OTSUKI Katsufumi

Department of Obstetrics and Gynecology, Showa University Koto Toyosu Hospital, Tokyo, Japan

Lactoferrin functions from studies in Reproductive medicine, Perinatology and Pediatrics

13:00 – 15:00 LUNCH

CHAIR PERSONS: VADIM VASYLIEV AND PIERA VALENTI

15:00 LACTOFERRIN FUNCTIONS FROM IN VITRO TO IN VIVO STUDIES
GASTROENTEROLOGY

(All the presentations include 5 min of discussion)

15:00 – 15:20 GRILC Blaž

Faculty of Pharmacy, Department of Pharmaceutical Technology, University of Ljubljana, Ljubljana, Slovenia

Development of enteric-coated pellets containing lactoferrin for local delivery into the small intestine

15:20 – 15:40 MA Xuanxuan (AWARD)

Key Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Beijing, China

Oral lactoferrin and antimicrobial peptide N6 for the treatment of bacterial enteritis caused by Escherichia coli in mice

15:40 – 16:00 ABAD Inés

Facultad de Veterinaria. Universidad de Zaragoza. Zaragoza, Spain

Lactoferrin reverses the intestinal alterations caused by antibiotic treatment in a murine model

16:00 – 16:20 GONZÁLEZ Luis (AWARD)

Instituto de Medicina Tropical Alexander von Humboldt, Lima, Peru

Oral lactoferrin administration does not impact the diversity or composition of the infant gut microbiota in a Peruvian cohort

16:30 – 17:00 COFFEE BREAK

17:00 LACTOFERRIN FUNCTIONS FROM IN VITRO TO IN VIVO STUDIES
– GYNECOLOGY
(All the presentations include 5 min of discussion)

17:00 – 17:30 OTSUKI Katsufumi

Department of Obstetrics and Gynecology, Showa University Koto Toyosu Hospital, Tokyo, Japan

Effects of lactoferrin in 30 patients with refractory bacterial vaginosis

17:30 – 17:50 WAŚ Kamila(AWARD)

Department of Microbiology, The Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Cracow, Poland

Microbiological study of lactoferrin’s impact on the growth of clinical isolates of vaginal lactobacilli. Implications for the use of lactoferrin to treat bacterial vaginosis

17:50 – 18:10 GELBFISH Gary

Department of Microbiology, The Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Cracow, Poland

Microbiological study of lactoferrin’s impact on the growth of clinical isolates of vaginal lactobacilli. Implications for the use of lactoferrin to treat bacterial vaginosis

18:10 LACTOFERRIN FUNCTIONS FROM IN VITRO TO IN VIVO STUDIES
– BONE REGENERATION AND WOUND HEALING
(All the presentations include 5 min of discussion)

18:10 – 18:40 CORNISH Jillian

Department of Medicine, University of Auckland, Auckland, New Zealand

Lactoferrin enhances the treatment of bone infections

18:40 – 19:00 ZHANG Kun (AWARD)

Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, China

The preparation of lactoferrin/NZ2114 dual-functional hydrogel and application in promoting wound healing

NOVEMBER 9th 2023

09:00-13:00 WALKING TOUR TO DISCOVER CARAVAGGIO, THE ROMAN BAROQUE AND RENAISSANCE

13:45 – 14:45 INTERNATIONAL COMMITTEE MEETING

CHAIR PERSONS: NIDIA LEON-SICAIROS AND LUIGI ROSA

15:00 LACTOFERRIN FUNCTIONS FROM IN VITRO TO IN VIVO STUDIES
– UROLOGY
(All the presentations include 5 min of discussion)

15:00 – 15:30 PAESANO Rosalba

Microbo s.r.l., Rome, Italy

Lactoferrin in the treatment of cystitis in in vitro and in vivo studies

15:30 LACTOFERRIN FUNCTIONS FROM IN VITRO TO IN VIVO STUDIES
– NEUROLOGY
(All the presentations include 5 min of discussion)

15:30 – 16:00 WANG Bing

Gulbali Institute, Charles Sturt University, Australia

Molecular characterization of lactoferrin receptor in response to dietary lactoferrin supplementation improves neurodevelopment and cognitive function in piglets

16:00 – 16:30 IANIRO Giusi (AWARD)

Department of Biosciences and Territory, University of Molise, Pesche, Italy

The effect of lactoferrin in a rotenone-induced Parkinson model

16:30 – 17:00 COFFEE BREAK

17:00 – 17:30 SIZONENKO Stéphane

Geneva University Hospital, Switzerland

Neuroprotective role of lactoferrin during brain development and injury through lifespan

17:30 LACTOFERRIN FUNCTIONS FROM IN VITRO TO IN VIVO STUDIES
– ONCOLOGY
(All the presentations include 5 min of discussion)

17:30 – 17:45 MA Jian

Central South University, Changsha, China

Lactoferrin is involved in the tumorigenesis of prostate cancer

17:45 – 18:00 BASTIDAS Daniela (AWARD)

Unidad de Investigación, Facultad de Medicina, Universidad Autónoma de Sinaloa, Sinaloa, México

Lactoferrin promotes immunomodulatory effects on leukocytes and cancer cell lines

18:00 – 19:00 GENEVIEVE SPIK AWARD

20:30 SOCIAL DINNER

NOVEMBER 10th 2023

CHAIR PERSONS: KATSUFUMI OTSUKI AND JIAHNUA WANG

09:00 NOVEL USES: ITALIAN AND INTERNATIONAL EXPERIENCES
(All the presentations include 5 min of discussion)

09:00 – 09:30 VASILYEV Vadim

Institute of Experimental Medicine Saint-Petersburg, Russia

Human holo-lactoferrin/oleic acid complex: efficient suppressor of tumor cells proliferation

09:30 – 10:00 DECEMBRINO Nunzia

AOU Policlinico “Rodolico-San Marco”, University of Catania, Italy

Oral lactoferrin supplementation reduces febrile neutropenia and sepsis and promotes gut eubiosis in children with hematological malignancies during induction chemotherapy

10:00 – 10:30 JUAREZ PEREZ Victor

Alaxia SAS, 30 rue Edouard Nieuport, 69008 Lyon, France

Safety and tolerability of inhaled lactoferrin in healthy volunteers

10:30 – 11:00 COFFEE BREAK

11:00 – 11:30 KUBO Shutaro

Morinaga Milk Industry Co., 5-1-83 Higashihara, Zama, Kanagawa, Japan

Effects of bovine lactoferrin on oral and throat conditions under low humidity environments: A randomized, double-blind, placebo-controlled crossover trial

11:30 – 11:50 SANCHES Eduardo Farias

Geneva University Hospital, Switzerland

Bovine lactoferrin as adjuvant strategy for boosting neuroprotection induced by hypothermia after brain hypoxia-ischemia in rats

11:50 – 12:20 SOKOLOV Alexey

Institute of Experimental Medicine Saint-Petersburg, Russia

Lactoferrin prevents halogenative and oxidative stress in rats with experimental hyperglycemia

12:20 – 12:30 CONCLUDING REMARKS